Greg Hawryluk^{MD & PhD Candidate.}

Gregory Hawryluk is a fourth year resident in neurosurgery currently completing a PhD in neural repair and regeneration through the Institute of Medical Science under the supervision of Dr. Michael G. Fehlings.

Research Interests: Greg’s research seeks to understand the mechanism by which transplanted cells improve functional recovery following spinal cord injury. 

Greg also has an interest in the management of CNS hemorrhage, and has published on the use of recombinant activated factor VII and more recently on the timing of acticoagulation resumption following central nervous system hemorrhage.

Thesis Title: Defining Neural Precursor Cell-Host Interactions to Optimize Repair of Traumatic Spinal Cord Injury

Thesis Synopsis Our group has previously shown that cellular transplantation leads to remyelination – or re-insulation – of nerves, but it is unclear if this accounts for the functional recovery noted in experimental animals.  Greg is exploring the possibility that transplanted cells additionally secrete repair-promoting substances (called trophins) into the injured spinal cord as well as the possibility that these cells preserve tissue in addition to replacing it.  Furthermore, he has explored whether these cells reduce scarring and inflammation. 

Publications

Fehlings MG, Hawryluk GW. Scarring after spinal cord injury. J Neurosurg Spine. 2010 Aug;13(2):165-7; discussion 167-8.

Hawryluk GW, Austin JW, Furlan JC, Lee JB, O'Kelly C, Fehlings MG. Management of anticoagulation following central nervous system hemorrhage in patients with high thromboembolic risk. J Thromb Haemost. 2010 Jul;8(7):1500-8.

Hawryluk GW, Fehlings MG: Cellular Transplantation Approaches for repair of the Injured Spinal Cord: Ongoing and Pending Clinical Trials. Topics in SCI Rehabilitation. 2009.14(4): 47-61.

Hawryluk GW, Fehlings MG. The center of the spinal cord may be central to its repair. Cell Stem Cell. 2008 Sep 11;3(3):230-2.

Hawryluk GW, Rowland J, Kwon BK, Fehlings MG. Protection and repair of the injured spinal cord: a review of completed, ongoing, and planned clinical trials for acute spinal cord injury.Neurosurg Focus. 2008;25(5):E14.

Rowland JW, Hawryluk GW, Kwon B, Fehlings MG. Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg Focus. 2008;25(5):E2.

Hawryluk GW: Neurology. In: Comprehensive Neurosurgery Board Review 2nd Ed. Thieme. Ed. MacDonald, Loch. 2009.

Hawryluk GW, Fehlings MG: Striving for Perfection: The Evolution of Classification Systems for Neurological Function Following Human Spinal Cord Injury. In: The AO Manual of Spine Severity Measures and Instruments. Thieme. Eds. Chapman, Hanson, Dettori, and Norvell, 2008

Hawryluk GW, Cusimano MD. The role of recombinant activated factor VII in neurosurgery: hope or hype? J Neurosurg. 2006 Dec;105(6):859-68.

Chen L, Reece C, O'Keefe SL, Hawryluk GW, Engstrom MM, Hodgetts RB. Induction of the early-late Ddc gene during Drosophila metamorphosis by the ecdysone receptor. Mech Dev. 2002 Jun;114(1-2):95-107.

Hawryluk GW, Cadotte D, Fehlings MG: Acute Spinal Cord Injury: Initial Therapies. In: eHandbook Spine Ed. Harrop J. Accepted, Publication Pending.

Cadotte D, Hawryluk GW, Fehlings MG: Acute Spinal Cord Injury: Timing of Therapy. In: eHandbook Spine Ed. Harrop J. Accepted, Publication Pending.

Hawryluk GW, Fehlings MG: Development and Maturation of the Spinal Cord: Implications of Molecular and Genetic Defects. In: Handbook of Clinical Neurology Ed. Verhaagen J. Accepted, Publication Pending

Hawryluk GW, Fehlings MG: Current Status and Future Direction of Spinal Cord Injury Management. In: Yeoman’s Neurological Surgery Ed. Winn R. Accepted, Publication Pending.

Zacko CJ, Hawryluk GW, Bullock RM: Neurochemical Pathomechanisms in Traumatic Brain Injury. In: Yeoman’s Neurological Surgery Ed. Winn R. Accepted, Publication Pending.

Hawryluk GW, Kwon B, Fehlings MG: Translational Research in Spinal Cord Injury. In: Management of Spine and Spinal Cord Trauma. Thieme. Eds Fehlings MG, Vaccaro A. Accepted, Publication Pending.

Wang S, Hawryluk GW, Fehlings MG: Neuroprotective Trials in Spinal Cord Injury. In: Spine and Spinal Cord Trauma: Evidence-Based Management Eds. Vaccaro, Fehlings, Dvorak. Accepted, Publication Pending.

Wang S, Hawryluk GW, Fehlings MG: Spinal Cord Injury: Pharmacologic Protocols for Injured Athletes. In: Seminars in Spine Surgery. Ed Hecht A. Accepted, Publication Pending.

Rowland J, Hawryluk GW, Kwon B, Fehlings MG: Emerging Regeneration and Repair Strategies for Spinal Cord Injury. In: Management of Spine and Spinal Cord Trauma. Thieme. Eds Fehlings MG, Vaccaro A. Accepted, Publication Pending.